The following applies to all three installments of the first Guild Wars:
Guild Wars: Factions,
Guild Wars: Eye of the North.
Guild Wars 2 has similar accessibility but its click to move capabilities have been changed to the worse.
Can be played with mouse only.
Fullscreen or windowed.
Controls are fully customizable.
Energy is shown in red, Mana in blue, Skillpoints in green.
GUI can be positioned wherever you like. It can be resized, too.
Please add information if you can.