Windowed or fullscreen.
Mouse only. LMB and click-dragging only.
Game menu can be accessed by mouse.
Sometimes clicking is not very accurate, so if there's no reaction it is quite possible that it didn't recognize the click. But mind you, sometimes things are supposed not to do anything but what didn't work once may change over the course of the game.
Visuals are rather problematic because of tiny hints and texts on the game screen. There is little narrative text. Windows Magnifyer works.